2. Academic Validation
  3. 5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

  • Bioorg Med Chem Lett. 2003 May 5;13(9):1543-7. doi: 10.1016/s0960-894x(03)00180-x.
Patrick Angibaud 1,  Xavier Bourdrez,  Ann Devine,  David W End,  Eddy Freyne,  Yannick Ligny,  Philippe Muller,  Geert Mannens,  Isabelle Pilatte,  Virginie Poncelet,  Stacy Skrzat,  Gerda Smets,  Jacky Van Dun,  Pieter Van Remoortere,  Marc Venet,  Walter Wouters
Affiliations

Affiliation

  • 1 Medicinal Chemistry Department, Johnson & Johnson Pharmaceutical Research & Development, Campus de Maigremont BP615, 27106 Val de Reuil, France. [email protected]
PMID: 12699751 DOI: 10.1016/s0960-894x(03)00180-x
Abstract

The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.

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