2. Academic Validation
  3. Multidrug resistance reversal activity of key ningalin analogues

Multidrug resistance reversal activity of key ningalin analogues

  • Bioorg Med Chem Lett. 2003 May 19;13(10):1777-81. doi: 10.1016/s0960-894x(03)00294-4.
Danielle R Soenen 1,  Inkyu Hwang,  Michael P Hedrick,  Dale L Boger
Affiliations

Affiliation

  • 1 The Scripps Research Institute and the Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 12729663 DOI: 10.1016/s0960-894x(03)00294-4
Abstract

Key analogue derivatives of the ningalins, potent multidrug resistance (MDR) reversal compounds, were examined resulting in the discovery of a potent MDR reversal agent that hypersensitizes P-gp resistant tumor cell lines to front-line conventional therapeutic agents.

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