2. Academic Validation
  3. Callyspongenols A-C, new cytotoxic C22-polyacetylenic alcohols from a red sea sponge, Callyspongia species

Callyspongenols A-C, new cytotoxic C22-polyacetylenic alcohols from a red sea sponge, Callyspongia species

  • J Nat Prod. 2003 May;66(5):679-81. doi: 10.1021/np030006c.
Diaa T A Youssef 1,  Rob W M van Soest,  Nobuhiro Fusetani
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
PMID: 12762806 DOI: 10.1021/np030006c
Abstract

Investigation of the organic extract of a Red Sea Sponge, Callyspongia sp., resulted in isolation and identification of three new C(22)-polyacetylenic alcohols, callyspongenols A-C (1-3), together with dehydroisophonochalynol (4). The structures of 1-3 were determined by 1D and 2D NMR studies and mass spectral determinations. Compounds 1-4 showed moderate cytotoxicity against P388 and HeLa cells.

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