2. Academic Validation
  3. Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate derivatives and evaluation of their antimalarial activities

Synthesis of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate derivatives and evaluation of their antimalarial activities

  • J Med Chem. 2003 Jun 5;46(12):2397-403. doi: 10.1021/jm020452h.
Nongpanga Ningsanont 1,  David St C Black,  Rachada Chanphen,  Yodhathai Thebtaranonth
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand.
PMID: 12773043 DOI: 10.1021/jm020452h
Abstract

Derivatives of ethyl 5-phenyl-6-oxa-1-azabicyclo[3.1.0]hexane-2-carboxylate (14-20), with side chains varying from three to five carbon atoms and bearing various substituents, have been prepared from ethyl 2-phenyl-1-pyrroline-5-carboxylate (12). Their in vitro activity against P. falciparum (K1 strain) and antimycobacterium and also their cytotoxic activity against Vero cell have been evaluated.

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