2. Academic Validation
  3. Rocks: multifunctional kinases in cell behaviour

Rocks: multifunctional kinases in cell behaviour

  • Nat Rev Mol Cell Biol. 2003 Jun;4(6):446-56. doi: 10.1038/nrm1128.
Kirsi Riento 1,  Anne J Ridley
Affiliations

Affiliation

  • 1 Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK. [email protected]
PMID: 12778124 DOI: 10.1038/nrm1128
Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

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