2. Academic Validation
  3. Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

Acetogenins as selective inhibitors of the human ovarian 1A9 tumor cell line

  • J Med Chem. 2003 Jul 17;46(15):3185-8. doi: 10.1021/jm020548b.
Yuka Nakanishi 1,  Fang-Rong Chang,  Chih-Chuang Liaw,  Yang-Chang Wu,  Kenneth F Bastow,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA.
PMID: 12852747 DOI: 10.1021/jm020548b
Abstract

Several bioactive acetogenins were selective against 1A9 (ovarian Cancer) cell replication but did not show a corresponding hyperactivity against Other cell lines. The most active compound (26, molvizarin) was a selective inhibitor of 1A9 cell replication with a potency (ED(50) = 5 pg/mL) of over 1 million times more than that for Other cell lines.

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