2. Academic Validation
  3. Effect of catechol derivatives on cell growth and lipoxygenase activity

Effect of catechol derivatives on cell growth and lipoxygenase activity

  • Bioorg Med Chem Lett. 2003 Aug 4;13(15):2435-9. doi: 10.1016/s0960-894x(03)00528-6.
Julie Simpson 1,  Rebecca Forrester,  Michael J Tisdale,  David C Billington,  Daniel L Rathbone
Affiliations

Affiliation

  • 1 School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK.
PMID: 12852938 DOI: 10.1016/s0960-894x(03)00528-6
Abstract

Derivatives of salicylic acid have been synthesized as potential Lipoxygenase inhibitors. Agents containing a phenolic dihydroxy moiety showed potent (IC(50)10(-6)-10(-7) M) inhibition of the growth of murine colonic tumour cells in vitro, and were effective inhibitors of 5-, 12- and 15-lipoxygenase in intact cells. The catechols were also potent inhibitors of rabbit reticulocyte 15-lipoxygenase (IC(50) approximately 1 microM).

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