2. Academic Validation
  3. The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?

The design and synthesis of guanosine compounds with in vitro activity against the colon cancer cell line SW480: non-taxane derived mimics of taxol?

  • Bioorg Med Chem Lett. 2003 Aug 18;13(16):2693-7. doi: 10.1016/s0960-894x(03)00543-2.
Joshua Howarth 1,  Padraic Kenny,  Susan McDonnell,  Aine O'Connor
Affiliations

Affiliation

  • 1 School of Chemical Sciences, Dublin City University, Dublin 9, Ireland. [email protected]
PMID: 12873496 DOI: 10.1016/s0960-894x(03)00543-2
Abstract

In the course of our investigation into the use of taxol as a lead compound to design new molecules with anti-cancer activity, we have synthesized four compounds based on protected guanosine coupled to taxol isoserine side-chain analogues. These analogues show in vitro anti-cancer activity against the colon Cancer cell line SW480 that their constituent parts do not.

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