2. Academic Validation
  3. Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives

  • Bioorg Med Chem Lett. 2003 Oct 6;13(19):3137-40. doi: 10.1016/s0960-894x(03)00724-8.
Young-Jae You 1,  Yong Kim,  Nguyen-Hai Nam,  Byung-Zun Ahn
Affiliations

Affiliation

  • 1 College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea.
PMID: 12951080 DOI: 10.1016/s0960-894x(03)00724-8
Abstract

New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 Cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

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