2. Academic Validation
  3. Role of perlecan in skeletal development and diseases

Role of perlecan in skeletal development and diseases

  • Glycoconj J. 2002 May-Jun;19(4-5):263-7. doi: 10.1023/A:1025340215261.
John Hassell 1,  Yoshihiko Yamada,  Eri Arikawa-Hirasawa
Affiliations

Affiliation

  • 1 The Center for Research in Skeletal Development and Pediatric Orthopaedics, Shriners Hospitals for Children, Tampa, FL 33612, USA. [email protected]
PMID: 12975604 DOI: 10.1023/A:1025340215261
Abstract

Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization. Recent studies with gene knockout mice and human diseases revealed critical in vivo roles of perlecan in cartilage development and neuromuscular junction activity.

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