2. Academic Validation
  3. Action of two ethyl thiol esters against experimental tuberculosis in the guinea-pig

Action of two ethyl thiol esters against experimental tuberculosis in the guinea-pig

  • Br J Pharmacol Chemother. 1960 Mar;15(1):122-7. doi: 10.1111/j.1476-5381.1960.tb01219.x.
G E DAVIES,  G W DRIVER
PMID: 13814392 DOI: 10.1111/j.1476-5381.1960.tb01219.x
Abstract

Two thiol esters, ethyl dithiolterephthalate (Compound 13,130) and ditophal (ethyl dithiolisophthalate; Etisul), have been tested for their antituberculosis activity in guinea-pigs. Compound 13,130 was active at a dose of 100 mg./Kg. twice daily by mouth in Animals infected subcutaneously, but was inactive against an intracerebral Infection at 50 mg./kg. Ditophal was active in the subcutaneously infected Animals at 200 mg./kg. orally or 50 mg./kg. subcutaneously. Higher doses subcutaneously were irritant.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-118647
    Anti-tuberculosis/Anti-leprosy Agent