2. Academic Validation
  3. Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents

Novel non-cross resistant diaminoanthraquinones as potential chemotherapeutic agents

  • J Med Chem. 1992 Nov 13;35(23):4259-63. doi: 10.1021/jm00101a001.
J B Jiang 1,  M G Johnson,  J M Defauw,  T M Beine,  L M Ballas,  W P Janzen,  C R Loomis,  J Seldin,  D Cofield,  L Adams
Affiliations

Affiliation

  • 1 Department of Chemical Research, Sphinx Pharmaceuticals Corporation, Durham, North Carolina 27717.
PMID: 1447730 DOI: 10.1021/jm00101a001
Abstract

A novel series of diaminoanthraquinones was discovered initially as protein kinase C inhibitors with IC50s in the 50-100 microM range. They exhibited potent tumor cell growth inhibitory activity in vitro without cross resistance to adriamycin. Further evaluation of two of the most active compounds NSC 639365 (3) and NSC 639366 (4) in human tumor cloning assay showed potent cytocidal activity. The results suggest therapeutical potentials against human tumors.

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