2. Academic Validation
  3. Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

Regioselective synthesis and cytotoxicities of camptothecin derivatives modified at the 7-, 10- and 20-positions

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3739-41. doi: 10.1016/j.bmcl.2003.08.012.
Xian-dao Pan 1,  Rui Han,  Piao-yang Sun
Affiliations

Affiliation

  • 1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. [email protected]
PMID: 14552770 DOI: 10.1016/j.bmcl.2003.08.012
Abstract

A series of 7-acyloxymethylcamptothecin and 20-O-acyl-7-acyloxymethylcamptothecin derivatives were regioselectively prepared on different Solvents. 7-Acyloxymethylcamptothecins possess more efficacy than 20-O-acyl-7-acyloxymethylcamptothecins against six human Cancer cell lines in vitro.

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