2. Academic Validation
  3. Cytotoxic constituents of Isodon rubescens var. lushiensis

Cytotoxic constituents of Isodon rubescens var. lushiensis

  • J Nat Prod. 2003 Oct;66(10):1391-4. doi: 10.1021/np030165w.
Quan-Bin Han 1,  Ai-Hua Zhao,  Ji-Xia Zhang,  Yang Lu,  Li-Li Zhang,  Qi-Tai Zheng,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 14575445 DOI: 10.1021/np030165w
Abstract

Five new ent-kaurane Diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

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