2. Academic Validation
  3. Synthesis and antiproliferative activity of retroetoposide

Synthesis and antiproliferative activity of retroetoposide

  • Bioorg Med Chem Lett. 2003 Nov 17;13(22):4107-9. doi: 10.1016/j.bmcl.2003.08.044.
Philippe Meresse 1,  Prokopios Magiatis,  Emmanuel Bertounesque,  Claude Monneret
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacochimie, UMR 176 CNRS-Institut Curie, Section Recherche, 26 rue d'Ulm, 75248 Paris cedex 05, France.
PMID: 14592517 DOI: 10.1016/j.bmcl.2003.08.044
Abstract

Retro-4'-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4'-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-beta-D-glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.

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