2. Academic Validation
  3. New cinnamylphenols from Dalbergia species with cancer chemopreventive activity

New cinnamylphenols from Dalbergia species with cancer chemopreventive activity

  • J Nat Prod. 2003 Dec;66(12):1574-7. doi: 10.1021/np0302450.
Chihiro Ito 1,  Masataka Itoigawa,  Tetsufumi Kanematsu,  Nijsiri Ruangrungsi,  Hiroshi Higashihara,  Harukuni Tokuda,  Hoyoku Nishino,  Hiroshi Furukawa
Affiliations

Affiliation

  • 1 Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
PMID: 14695799 DOI: 10.1021/np0302450
Abstract

Five new cinnamylphenols (1,3-diphenylpropenes), dalberatins A (1), B (2), C (3), D (4), and E (5), were isolated from Plants of the Dalbergia species. They were characterized and tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The cinnamylphenols were found to show remarkably potent activities. The result of the present investigation indicated that some of these cinnamylphenols might be valuable as potential Cancer chemopreventive agents (anti-tumor promoters).

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