2. Academic Validation
  3. Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents

Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents

  • Bioorg Med Chem Lett. 2004 Mar 22;14(6):1581-4. doi: 10.1016/j.bmcl.2003.12.096.
Zhiyan Xiao 1,  Shiqing Han,  Kenneth F Bastow,  Kuo-Hsiung Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360, USA.
PMID: 15006408 DOI: 10.1016/j.bmcl.2003.12.096
Abstract

An 11,13-O,O'-cyclosulfite GL-331 analogue (7) was synthesized in six steps from podophyllotoxin and evaluated as a potential antitumor agent. Compound 7 was significantly cytotoxic against human tumor cell lines, but showed no inhibition against human DNA Topoisomerase II in vitro. This compound represents a novel prototype of antitumor podophyllotoxin analogues.

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