2. Academic Validation
  3. 7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases

7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases

  • J Med Chem. 2004 Mar 25;47(7):1599-601. doi: 10.1021/jm0499458.
Diane H Boschelli 1,  Yanong D Wang,  Steve Johnson,  Biqi Wu,  Fei Ye,  Ana Carolina Barrios Sosa,  Jennifer M Golas,  Frank Boschelli
Affiliations

Affiliation

  • 1 Chemical and Screening Sciences and Oncology, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA. [email protected]
PMID: 15027848 DOI: 10.1021/jm0499458
Abstract

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.

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