2. Academic Validation
  3. New cytotoxic metabolites from a marine sponge Homaxinella sp

New cytotoxic metabolites from a marine sponge Homaxinella sp

  • J Nat Prod. 2004 Apr;67(4):721-4. doi: 10.1021/np030358j.
Tayyab A Mansoor 1,  Jongki Hong,  Chong-O Lee,  Chung Ja Sim,  Kwang Sik Im,  Dong Seok Lee,  Jee H Jung
Affiliations

Affiliation

  • 1 College of Pharmacy, Pusan National University, Busan 609-735, Korea.
PMID: 15104515 DOI: 10.1021/np030358j
Abstract

Three new butenolides (1-3), a new cyclopentenone derivative (4), and a known alcohol (5) were isolated from a marine Sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures were established on the basis of NMR and MS analyses. The stereochemistry of the butenolides and cyclopentenone derivative was defined on the basis of optical rotation and CD spectroscopy. The compounds were tested for cytotoxicity against a panel of five human solid tumor cell lines and displayed marginal to significant activity.

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