2. Academic Validation
  3. Dissecting the functional role of different isoforms of the L-type Ca2+ channel

Dissecting the functional role of different isoforms of the L-type Ca2+ channel

  • J Clin Invest. 2004 May;113(10):1382-4. doi: 10.1172/JCI21815.
Emmanuel Bourinet 1,  Matteo E Mangoni,  Joël Nargeot
Affiliations

Affiliation

  • 1 Département de Physiologie, Laboratoire de Génomique Fonctionnelle, Centre National de la Recherche Scientifique Unité Propre de Recherche 2580, Montpellier, France. [email protected]
PMID: 15146233 DOI: 10.1172/JCI21815
Abstract

There currently exist a great number of different mouse lines in which the activity of a particular gene of interest has been inactivated or enhanced. However, it is also possible to insert specific mutations in a gene so that the pharmacological sensitivity of the gene product is altered. An example of such an approach shows how the abolition of the sensitivity of an L-type CA(2+) channel isoform to dihydropyridines allows the investigation of the physiological role of these channels in different tissues.

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