2. Academic Validation
  3. In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase

  • Bioorg Med Chem Lett. 2004 Jun 21;14(12):3155-9. doi: 10.1016/j.bmcl.2004.04.015.
Derek B Lowe 1,  Steven Magnuson,  Ning Qi,  Ann-Marie Campbell,  James Cook,  Zhenqiu Hong,  Ming Wang,  Mareli Rodriguez,  Furahi Achebe,  Harold Kluender,  Wai C Wong,  William H Bullock,  Arthur I Salhanick,  Terri Witman-Jones,  Mary E Bowling,  Christine Keiper,  Kevin B Clairmont
Affiliations

Affiliation

  • 1 Department of Chemistry Research, Bayer Research Center, 400 Morgan Lane, West Haven, CT 06516, USA. [email protected]
PMID: 15149665 DOI: 10.1016/j.bmcl.2004.04.015
Abstract

A series of (5-(2H)-isoxazolonyl) ureas were developed as nanomolar inhibitors of hormone-sensitive Lipase, an enzyme of potential importance in the treatment of diabetes.

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