2. Academic Validation
  3. Synthesis and structure-activity relationships of 1,5-diazaanthraquinones as antitumour compounds

Synthesis and structure-activity relationships of 1,5-diazaanthraquinones as antitumour compounds

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):3929-32. doi: 10.1016/j.bmcl.2004.05.055.
Carmen Avendaño 1,  José María Pérez,  Maria del Mar Blanco,  Jesús Angel de la Fuente,  Sonia Manzanaro,  María Jesús Vicent,  María Jesús Martín,  Nélida Salvador-Tormo,  J Carlos Menéndez
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
PMID: 15225700 DOI: 10.1016/j.bmcl.2004.05.055
Abstract

1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC(50) values in the 10(-8)M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as Anticancer agents.

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