2. Academic Validation
  3. Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

  • Bioorg Med Chem Lett. 2004 Aug 2;14(15):4107-11. doi: 10.1016/j.bmcl.2004.04.087.
Ahmed Kamal 1,  O Srinivas,  P Ramulu,  G Ramesh,  P Praveen Kumar
Affiliations

Affiliation

  • 1 Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. [email protected]
PMID: 15225736 DOI: 10.1016/j.bmcl.2004.04.087
Abstract

Pyrrolobenzodiazepine hybrids linked to acridone/acridine ring systems at C8-position have been designed and prepared that exhibit significant DNA-binding affinity, and a representative compound shows promising in vitro Anticancer activity.

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