Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer

Bioorg Med Chem Lett. 2004 Oct 4;14(19):4919-23. doi: 10.1016/j.bmcl.2004.07.026.

Veeresa Gududuru ¹, Eunju Hurh, Gangadhar G Durgam, Seoung Soo Hong, Vineet M Sardar, Huiping Xu, James T Dalton, Duane D Miller

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Affiliation

1 Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN 38163, USA.

PMID: 15341952 DOI: 10.1016/j.bmcl.2004.07.026

Abstract

We describe herein synthesis, SAR, and biological evaluation of a novel series of cytotoxic serine amide phosphates (SAPs) for prostate Cancer. These compounds were tested for their cytotoxicity in five human prostate Cancer cell lines (DU-145, PC-3, LNCaP, PPC-1, and TSU), and in CHO and RH7777 cells (negative controls). Comparison of Anticancer effects of these compounds with a standard chemotherapeutic agent 5-fluorouracil shows that they are very effective in killing prostate Cancer cells with low micromolar cytotoxicity and provide us a new lead for the development of drugs for prostate Cancer.

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