2. Academic Validation
  3. Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia

  • Bioorg Med Chem Lett. 2004 Sep 6;14(17):4545-8. doi: 10.1016/j.bmcl.2004.06.034.
Jean Jacques Vanden Eynde 1,  Annie Mayence,  Tien L Huang,  Margaret S Collins,  Sandra Rebholz,  Peter D Walzer,  Melanie T Cushion
Affiliations

Affiliation

  • 1 Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans 70125, USA.
PMID: 15357989 DOI: 10.1016/j.bmcl.2004.06.034
Abstract

A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.

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