2. Academic Validation
  3. New diterpenoids from the marine mangrove Bruguiera gymnorrhiza

New diterpenoids from the marine mangrove Bruguiera gymnorrhiza

  • J Nat Prod. 2004 Sep;67(9):1620-3. doi: 10.1021/np040062t.
Li Han 1,  Xueshi Huang,  Isabel Sattler,  Hans-Martin Dahse,  Hongzheng Fu,  Wenhan Lin,  Susanne Grabley
Affiliations

Affiliation

  • 1 National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
PMID: 15387677 DOI: 10.1021/np040062t
Abstract

Phytochemical investigation of the stem of Bruguiera gymnorrhiza yielded three new ent-kaurane Diterpenoids (1, 2, and 3) and one new ent-beyerane diterpenoid (4) together with nine known ent-kaurane Diterpenoids. All structures and the relative stereochemistry of the new compounds were determined by NMR spectroscopic studies. The absolute stereochemistry of 4 was determined by CD data. Some of the compounds showed moderate cytotoxic properties.

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