2. Academic Validation
  3. Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives

  • Bioorg Med Chem Lett. 2004 Dec 20;14(24):5979-81. doi: 10.1016/j.bmcl.2004.10.002.
Houchao Tao 1,  Inkyu Hwang,  Dale L Boger
Affiliations

Affiliation

  • 1 Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
PMID: 15546712 DOI: 10.1016/j.bmcl.2004.10.002
Abstract

A series of amide derivatives of permethyl ningalin B were prepared and examined as multidrug resistance (MDR) reversal agents illustrating that the C5 carboxylate is widely tolerant of such derivatization.

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