2. Academic Validation
  3. Novel diarylsulfonylurea derivatives as potent antimitotic agents

Novel diarylsulfonylurea derivatives as potent antimitotic agents

  • Bioorg Med Chem Lett. 2004 Dec 20;14(24):6075-8. doi: 10.1016/j.bmcl.2004.09.069.
Semi Kim 1,  Ji Hyun Park,  Sun-Young Koo,  Jung In Kim,  Min-Hyeung Kim,  Ji Eun Kim,  Kiwon Jo,  Hwan Geun Choi,  Sung Bae Lee,  Sang-Hun Jung
Affiliations

Affiliation

  • 1 LG Life Sciences, Ltd/R&D Park, 104-1 Moonji-dong, Yuseong-gu, Daejon 305-380, South Korea. [email protected]
PMID: 15546733 DOI: 10.1016/j.bmcl.2004.09.069
Abstract

A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human Cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant Cancer cells, which are resistant to many Other known microtubule inhibitors.

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