2. Academic Validation
  3. Optimization of pyrrolidinone based HIV protease inhibitors

Optimization of pyrrolidinone based HIV protease inhibitors

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):81-4. doi: 10.1016/j.bmcl.2004.10.029.
Ronald G Sherrill 1,  C Webster Andrews,  William J Bock,  Ronda G Davis-Ward,  Eric S Furfine,  Richard J Hazen,  Randy D Rutkowske,  Andrew Spaltenstein,  Lois L Wright
Affiliations

Affiliation

  • 1 GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]
PMID: 15582415 DOI: 10.1016/j.bmcl.2004.10.029
Abstract

Optimization of P1-substituted pyrrolidinone based HIV Protease Inhibitors has yielded analogs with very potent Antiviral activity.

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