2. Academic Validation
  3. 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis

  • Bioorg Med Chem Lett. 2005 Mar 15;15(6):1557-60. doi: 10.1016/j.bmcl.2005.01.078.
Irina Shcherbakova 1,  Manuel F Balandrin,  John Fox,  Anjan Ghatak,  William L Heaton,  Rebecca L Conklin
Affiliations

Affiliation

  • 1 Drug Discovery, NPS Pharmaceuticals, Inc., 383 Colorow Drive, Salt Lake City, UT 84108, USA. [email protected]
PMID: 15745796 DOI: 10.1016/j.bmcl.2005.01.078
Abstract

Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit, resulted in the discovery of potent calcium receptor antagonists, substituted 3H-quinazolin-4-ones.

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