2. Academic Validation
  3. 3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells

  • Bioorg Med Chem Lett. 2005 Mar 15;15(6):1633-6. doi: 10.1016/j.bmcl.2005.01.054.
Jonathan R Dimmock 1,  Umashankar Das,  H Inci Gul,  Masami Kawase,  Hiroshi Sakagami,  Zoltán Baráth,  Imre Ocsovsky,  Joseph Molnár
Affiliations

Affiliation

  • 1 College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. [email protected]
PMID: 15745812 DOI: 10.1016/j.bmcl.2005.01.054
Abstract

The incorporation of the 1-aryl-5-(4-nitrophenyl)-3-oxo-1,4-pentadienyl group into 3,4-dihydro-1H-naphthalenyl, cyclohexyl, 2,3-dihydro-1H-indenyl and cyclopentyl scaffolds led to the discovery of various compounds with selective toxicity for malignant cells and ability to reverse multidrug resistance.

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