2. Academic Validation
  3. Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains

Synthesis and in vitro antitumor activity of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains

  • Bioorg Med Chem Lett. 2005 Apr 1;15(7):1915-7. doi: 10.1016/j.bmcl.2005.01.083.
Sheng-Li Cao 1,  Yu-Ping Feng,  Yu-Yang Jiang,  Shi-Ying Liu,  Guo-Yu Ding,  Run-Tao Li
Affiliations

Affiliation

  • 1 Department of Chemistry, Capital Normal University, Beijing 100037, China. [email protected]
PMID: 15780632 DOI: 10.1016/j.bmcl.2005.01.083
Abstract

A series of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains were synthesized and tested for their in vitro antitumor activity against human myelogenous leukemia K562 cells. Among them, (3,4-dihydro-2-methyl-4-oxoquinazolin-6-yl)methyl 4-(4-fluorophenyl)piperazine-1-carbodithioate 8q exhibited significant inhibitory activity against K562 cells with IC(50) value of 0.5 microM.

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