2. Academic Validation
  3. Lancifodilactone F: a novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity

Lancifodilactone F: a novel nortriterpenoid possessing a unique skeleton from Schisandra lancifolia and its anti-HIV activity

  • Org Lett. 2005 Mar 31;7(7):1263-6. doi: 10.1021/ol0473187.
Wei-Lie Xiao 1,  Rong-Tao Li,  Sheng-Hong Li,  Xiao-Li Li,  Han-Dong Sun,  Yong-Tang Zheng,  Rui-Rui Wang,  Yang Lu,  Cheng Wang,  Qi-Tai Zheng
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P R China.
PMID: 15787482 DOI: 10.1021/ol0473187
Abstract

[structures: see text] Lancifodilactone F (1), possessing an unprecedented rearranged pentanortriterpenoid backbone derived from cycloartane, was isolated from the leaves and stems of Schisandra lancifolia (Rehd. et Wils) A. C. Smith. Its structure was established by comprehensive NMR and MS spectroscopic analysis, coupled with single-crystal X-ray experiment. Compound 1 exerted minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and showed anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62.

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