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  3. A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

A chiral molecular recognition approach to the formation of optically active quaternary centres in aza-Henry reactions

  • Org Biomol Chem. 2005 Apr 21;3(8):1362-4. doi: 10.1039/b500618j.
Kristian Rahbek Knudsen 1,  Karl Anker Jorgensen
Affiliations

Affiliation

  • 1 Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Denmark.
PMID: 15827627 DOI: 10.1039/b500618j
Abstract

An approach to asymmetric catalysis based on chiral molecular recognition by the combination of chiral Lewis acids and chiral organocatalysis for the formation of optically active quarternary centers in the aza-Henry reaction is presented; this procedure leads to products with up to 98% ee and a diastereomeric ratio of 14 : 1 in excellent yields with catalyst loadings of 5 mol%.

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