2. Academic Validation
  3. Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones

Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones

  • Bioorg Med Chem Lett. 2005 May 2;15(9):2291-4. doi: 10.1016/j.bmcl.2005.03.016.
Paola Barraja 1,  Laura Sciabica,  Patrizia Diana,  Antonino Lauria,  Alessandra Montalbano,  Anna Maria Almerico,  Gaetano Dattolo,  Girolamo Cirrincione,  Silvia Disarò,  Giuseppe Basso,  Giampietro Viola,  Francesco Dall'Acqua
Affiliations

Affiliation

  • 1 Dipartimento Farmacochimico, Tossicologico e Biologico, Università degli Studi di Palermo Via Archirafi 32, 90123 Palermo, Italy.
PMID: 15837311 DOI: 10.1016/j.bmcl.2005.03.016
Abstract

A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.

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