2. Academic Validation
  3. Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

Cytotoxic arylnaphthalene lignans from a Vietnamese acanthaceae, Justicia patentiflora

  • J Nat Prod. 2005 May;68(5):734-8. doi: 10.1021/np050028u.
Sophie Susplugas 1,  Nguyen Van Hung,  Jérôme Bignon,  Odile Thoison,  Anna Kruczynski,  Thierry Sévenet,  Françoise Guéritte
Affiliations

Affiliation

  • 1 Institut de Chimie des Substances Naturelles, CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
PMID: 15921419 DOI: 10.1021/np050028u
Abstract

One new norlignan (1) and five new Lignans (2-6) were isolated from the leaves and stems of Justicia patentiflora by a bioassay-guided purification. Five known compounds, carinatone, diphyllin, justicidin A, taiwanin E, and tuberculatin, were also found in J. patentiflora. Most of the new compounds display significant activity in in vitro cytotoxic assays against KB, HCT116, and MCF-7 Cancer cell lines and arrest the cell cycle in the G0/G1 phase.

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