2. Academic Validation
  3. New cytotoxic isoflavone from the root bark of Brosimum utile

New cytotoxic isoflavone from the root bark of Brosimum utile

  • Nat Prod Res. 2005 Jun;19(4):331-5. doi: 10.1080/14786410412331280014.
Franco Ferrari 1,  Franco Delle Monache,  Alírica I Suárez,  Francisco Arvelo,  Reinaldo S Compagnone
Affiliations

Affiliation

  • 1 Istituto di Chimica del Riconoscimento Molecolare CNR, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, Italy.
PMID: 15938138 DOI: 10.1080/14786410412331280014
Abstract

A new isoflavone 5,7,4'-trihydroxy-3'-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known Isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon Cancer) and human dermis fibroblasts.

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