2. Academic Validation
  3. Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

  • Bioorg Med Chem Lett. 2005 Aug 1;15(15):3560-4. doi: 10.1016/j.bmcl.2005.05.101.
Ronald G Sherrill 1,  Eric S Furfine,  Richard J Hazen,  John F Miller,  David J Reynolds,  Douglas M Sammond,  Andrew Spaltenstein,  Pat Wheelan,  Lois L Wright
Affiliations

Affiliation

  • 1 GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. [email protected]
PMID: 15975788 DOI: 10.1016/j.bmcl.2005.05.101
Abstract

A series of novel N-alkoxy-arylsulfonamide HIV Protease Inhibitors with low picomolar enzyme activity and single digit nanomolar Antiviral activity is disclosed.

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