2. Academic Validation
  3. Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin

Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin

  • Bioorg Med Chem Lett. 2005 Sep 15;15(18):4151-4. doi: 10.1016/j.bmcl.2005.06.004.
Shuhao Shi 1,  Shirong Zhu,  Samuel W Gerritz,  Kim Esposito,  Ramesh Padmanabha,  Wenying Li,  John J Herbst,  Henry Wong,  Yue Zhong Shu,  Kin S Lam,  Michael J Sofia
Affiliations

Affiliation

  • 1 New Leads Chemistry, 5 Research Parkway, Wallingford, CT 06492, USA. [email protected]
PMID: 16005213 DOI: 10.1016/j.bmcl.2005.06.004
Abstract

The solid-phase synthesis of a library based on the natural product anisomycin is described. The resulting library was tested against a panel of Bacterial and Fungal targets, and active compounds were identified in a Staphylococcus aureus whole-cell assay and an efflux-deficient Fungal whole-cell assay.

Figures