2. Academic Validation
  3. Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

Ligands with dual vitamin D3-agonistic and androgen-antagonistic activities

  • Bioorg Med Chem Lett. 2005 Oct 1;15(19):4327-31. doi: 10.1016/j.bmcl.2005.06.044.
Shinnosuke Hosoda 1,  Aya Tanatani,  Ken-ichi Wakabayashi,  Yusuke Nakano,  Hiroyuki Miyachi,  Kazuo Nagasawa,  Yuichi Hashimoto
Affiliations

Affiliation

  • 1 Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
PMID: 16019211 DOI: 10.1016/j.bmcl.2005.06.044
Abstract

Ligands possessing dual vitamin D3-agonistic (estimated as HL-60 monocytic cell differentiation induction) and androgen-antagonistic (estimated as testosterone-induced SC-3 cell growth inhibition) activities with various activity spectra were prepared based on a substituted bis-phenylmethane skeleton. Some of them were revealed to be potent androgen antagonists with a nonsecosteroidal vitamin D3 skeleton.

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