Biologically active gamma-lactones and methylketoalkenes from Lindera benzoin

J Nat Prod. 1992 Jan;55(1):71-83. doi: 10.1021/np50079a011.

J E Anderson ¹, W W Ma, D L Smith, C J Chang, J L McLaughlin

Affiliations

Affiliation

1 Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.

PMID: 1602301 DOI: 10.1021/np50079a011

Abstract

Brine shrimp lethality-directed fractionation of the 95% EtOH extract of ripe berries from Lindera benzoin led to the isolation of three new C21 alkane-alkene gamma-lactones designated isolinderanolide, isolinderenolide, and linderanolide as well as the known series of C17 and C19 obtusilactones (isoobtusilactone A, obtusilactone A, isoobtusilactone, and obtusilactone) previously isolated from Lindera obtusiloba. The novel (6Z,9Z,12Z)-pentadecatrien-2-one, the known (6Z,9Z)-pentadecadien-2-one, and the known (+)-(Z)-nerolidol were also isolated as bioactive compounds. The structural elucidation and biological activities of these compounds are reported.

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