2. Academic Validation
  3. Two triterpenoids and other constituents from Petasites tricholobus

Two triterpenoids and other constituents from Petasites tricholobus

  • Phytochemistry. 2005 Oct;66(19):2340-5. doi: 10.1016/j.phytochem.2005.03.032.
Wei-Dong Xie 1,  Qi Zhang,  Ping-Lin Li,  Zhong-Jian Jia
Affiliations

Affiliation

  • 1 Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
PMID: 16023687 DOI: 10.1016/j.phytochem.2005.03.032
Abstract

Two migrated ursane skeleton triterpenoids, one is D:B-friedoursane-3alpha,16alpha-dihydroxy-7alpha,8alpha-epoxy-5(10)-ene, named petatrichol A (1) and the other one represents a novel triterpenoid carbon framework, named petatrichol B (2), along with 10 known compounds were isolated from the rhizome of Petasites tricholobus. Their structures were elucidated on the basis of spectroscopic methods (IR, EIMS, HRMS, 1D and 2D NMR). The triterpenoids were assayed against Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Compounds 1 and 2 exhibited significant Antibacterial activity against B. subtilis.

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