2. Academic Validation
  3. 5'-Homoneplanocin A inhibits hepatitis B and hepatitis C

5'-Homoneplanocin A inhibits hepatitis B and hepatitis C

  • J Med Chem. 2005 Jul 28;48(15):5043-6. doi: 10.1021/jm058200e.
Minmin Yang 1,  Stewart W Schneller,  Brent Korba
Affiliations

Affiliation

  • 1 Department of Chemistry and Biochemistry, Chemistry Building, Auburn University, Auburn, Alabama 36849-5312, USA.
PMID: 16033283 DOI: 10.1021/jm058200e
Abstract

As an outgrowth of our program to develop an efficient synthesis of 5'-homoneplanocin A, its Antiviral potential was explored beyond that already in the literature. From that, this compound was found to have meaningful activity toward hepatitis B and hepatitis C, which represents an example of one agent effective toward both viruses. These data and an improved preparation of 5'-homoneplanocin A are reported.

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