2. Academic Validation
  3. A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function

  • Bioorg Med Chem Lett. 2006 Feb;16(3):718-21. doi: 10.1016/j.bmcl.2005.10.026.
Robert J Chambers 1,  Kristin Abrams,  Tessa A Castleberry,  John B Cheng,  Douglas A Fisher,  Ajith V Kamath,  Anthony Marfat,  David O Nettleton,  Joann D Pillar,  Eben D Salter,  Alissa L Sheils,  John T Shirley,  Claudia R Turner,  John P Umland,  Kelvin T Lam
Affiliations

Affiliation

  • 1 Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. [email protected]
PMID: 16263279 DOI: 10.1016/j.bmcl.2005.10.026
Abstract

Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.

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