2. Academic Validation
  3. Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

  • Bioorg Med Chem Lett. 2006 Feb 15;16(4):915-9. doi: 10.1016/j.bmcl.2005.10.104.
Ying Lu 1,  Zongru Guo,  Yanshen Guo,  Jun Feng,  Fengming Chu
Affiliations

Affiliation

  • 1 Department of Synthetic Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.
PMID: 16300944 DOI: 10.1016/j.bmcl.2005.10.104
Abstract

A series of 2-alkoxydihydrocinnamates were synthesized as PPARgamma and PPARalpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPARalpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes.

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