2. Academic Validation
  3. Synthesis and biological activity of (+)-hedychilactone A and its analogs from (+)-sclareolide

Synthesis and biological activity of (+)-hedychilactone A and its analogs from (+)-sclareolide

  • Bioorg Med Chem Lett. 2006 Mar 15;16(6):1656-9. doi: 10.1016/j.bmcl.2005.12.009.
Sangtae Oh 1,  In Howa Jeong,  Woon-Seob Shin,  Qian Wang,  Seokjoon Lee
Affiliations

Affiliation

  • 1 Department of Chemistry, Yonsei University, Wonju 220-710, Republic of Korea.
PMID: 16384699 DOI: 10.1016/j.bmcl.2005.12.009
Abstract

Natural product hedychilactone A (3) has been synthesized from (+)-sclareolide by an efficient route. Two of the synthetic intermediates, 10 and 12, have shown strong growth inhibition effects against five Cancer cell lines, human umbilical vein endothelial cell (HUVEC) and nitric oxide (NO) production. In particular, compound 15 showed selective inhibition activity against HUVEC growth without any cytotoxicity among tested Cancer cell lines.

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