2. Academic Validation
  3. Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

  • J Med Chem. 2006 Jan 12;49(1):31-4. doi: 10.1021/jm051060o.
Ravindranadh V Somu 1,  Helena Boshoff,  Chunhua Qiao,  Eric M Bennett,  Clifton E Barry 3rd,  Courtney C Aldrich
Affiliations

Affiliation

  • 1 Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PMID: 16392788 DOI: 10.1021/jm051060o
Abstract

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC(99) = 0.19 microM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in biosynthesis of the mycobactins.

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