2. Academic Validation
  3. 2-substituted furans from the roots of Polyalthia evecta

2-substituted furans from the roots of Polyalthia evecta

  • J Nat Prod. 2006 Jan;69(1):68-72. doi: 10.1021/np0503202.
Somdej Kanokmedhakul 1,  Kwanjai Kanokmedhakul,  Itsara Kantikeaw,  Nutchanat Phonkerd
Affiliations

Affiliation

  • 1 Department of Chemistry, Taxonomic Research Center, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. [email protected]
PMID: 16441071 DOI: 10.1021/np0503202
Abstract

Four new 2-substituted furans, 19-(2-furyl)nonadeca-5,7-diynoic acid (1), 19-(2-furyl)nonadeca-5-ynoic acid (2), 1-(2-furyl)pentacosa-7,9-diyne (3), and ester 21-(2-furyl)heneicosa-14,16-diyne-19-(2-furyl)nonadeca-5,7-diynoate (4) have been isolated from the roots of Polyalthia evecta. Their structures were established by spectroscopic techniques. Compounds 1 and 1a showed antiplasmodial activity. The acids 1 and 2 exhibited Antiviral activity against Herpes simplex type 1. In addition, 5 also showed cytotoxicity against the NCI-H187 cell line.

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