2. Academic Validation
  3. Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

  • J Med Chem. 2006 Feb 9;49(3):847-9. doi: 10.1021/jm0509851.
Yasuhiro Goto 1,  Sachie Arai-Otsuki,  Yukari Tachibana,  Daisuke Ichikawa,  Satoshi Ozaki,  Hiroyuki Takahashi,  Yoshikazu Iwasawa,  Osamu Okamoto,  Shoki Okuda,  Hisashi Ohta,  Takeshi Sagara
Affiliations

Affiliation

  • 1 Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co. Ltd., Okubo 3, Tsukuba 300-2611, Japan.
PMID: 16451050 DOI: 10.1021/jm0509851
Abstract

A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from a compound identified by random screening, an exploratory library that exhibited a diverse display of pharmacophores was designed. After evaluating ORL1 antagonistic activity, a highly focused library was designed based on 3D-pharmacophore similarity to known actives. A novel D-proline amide class was identified in this library and was found to possess potent ORL1 antagonistic activity.

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