2. Academic Validation
  3. Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate

  • Bioorg Med Chem Lett. 2006 Jun 1;16(11):2974-7. doi: 10.1016/j.bmcl.2006.02.066.
Yuqiang Wang 1,  Lianfa Li,  Wei Jiang,  Zhaoqi Yang,  Zaijun Zhang
Affiliations

Affiliation

  • 1 Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou 510632, China. [email protected]
PMID: 16563756 DOI: 10.1016/j.bmcl.2006.02.066
Abstract

A conjugate of DHA and doxorubicin (DHA-Dox) was synthesized, and its antitumor activity was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models including L1210 leukemia and B16 melanoma. DHA-Dox showed a greatly improved antitumor efficacy compared to free doxorubicin.

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